In vitro antioxidant and anticancer activity of crude ethanol extract of Mahkota Dewa (Phaleria macrocarpa) leaves

This study aimed to determine the antioxidant activity and potential cytotoxicity effects of crude ethanol extract Mahkota Dewa (Phaleria macrocarpa) leaves on breast cancer cell lines. The P. macrocarpa was carried out by 2,2-diphenylpicrylhydrazyl (DPPH) assay. total phenolic flavonoid contents were evaluated using Folin-ciocalteu aluminium chloride methods, respectively. cytotoxic effect lines (T47D) studied WST-1 (4-[3-(4-Iodophenyl)-2-(4-nitro-phenyl)-2H-5-tetrazolio]-1,3- benzene sulfonate) results showed that exhibited a high with IC50 39.86 µg mL-1. effective T47D cells also had (71.20 ± 0.88 mg GA g−1) content (21.50 2.02 QE g−1). in might be contributed its extract. an value 97 mL−1 against current demonstrated could applied as natural anticancer agent.